Ka la 15 Mmesa, 2022, tlhahiso ea sefofane sa Lecardipine hydrochloride main ring e ile ea phethoa ka nako e le 'ngoe,' me matla a hona joale a tlhahiso ke 5Mt / khoeli.
Lebitso la Senyesemane:Lercanidipine hydrochloride
Lebitso la lik'hemik'hale:1,4-Dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2 - [(3,3-di phenylpropyl) methylamino] -l, l-dimethylethyl methyl ester hydrochloride.
Nomoro ea CAS: 132866-11-6
Kopo:Bakeng sa phekolo ea meriana ea Lecardipine hydrochloride, e ke ke ea e-ba le phello e mpe maling a tsoekere le maemo a lipid, 'me e na le phello e matla ea antihypertensive.
Tebello ea 'maraka:
Ho na le bakuli ba fetang limilione tse 200 ba nang le khatello e phahameng ea mali Chaena, 'me ho na le bakuli ba bacha ba 10 milione ba nang le khatello e phahameng ea mali selemo se seng le se seng, bao boholo ba bona ba sa laoleheng, e leng se bakang liketsahalo tse phahameng tsa mathata a khatello ea kelello a kang stroke, le lefu la selemo le selemo Chaena Har'a 3. bakuli ba limilione ba nang le lefu la pelo, 50% e amana le khatello ea mali, 'me litšenyehelo tsa selemo le selemo tsa phekolo ea lefu la pelo ke li-yuan tse limilione tse likete tse 309.8.Lebaka la taolo e mpe ha se feela hore tlhokomeliso ea bakuli ka khatello ea mali le mathata a eona e hloka ho ntlafatsoa, empa hape le hore bakuli ba bangata ba hlokang ho noa litlhare tsa bophelo bohle ha ba latele melao le ho sitoa ho noa meriana letsatsi le leng le le leng Leha ho le joalo, sena se boetse se bontša hore Mmaraka oa lithethefatsi tsa antihypertensive o na le keketseho e ka bang teng.Ha e bapisoa le lithethefatsi tse tšoanang, locarbodipine hydrochloride e na le khetho e matla ea methapo ea mali.Thepa ea eona e ikhethang ea lipophilic e etsa hore e be butle le ho tšoarella phello ea antihypertensive Phello ea atherogenic, haholo-holo e loketseng bakuli ba khatello ea mali ba nang le atherosclerosis, e na le boleng bo phahameng ba ts'ebeliso ea bongaka le tebello e pharalletseng ea mmaraka.
Ketso ea Pharmacological:
Lecardipine ke moloko o mocha oa dihydropyridine calcium channel group hysteresis agent, e nang le khetho e matla ea methapo, phello e bonolo, phello e matla ea antihypertensive, nako e telele ea liketso, phello e fokolang ea inotropic joalo-joalo.Liphuputso tsa in vitro li fumane hore locarbodipine e na le phello e tobileng ea ho phomola mesifa e boreleli ea vascular, ka hona e na le phello e matla ea antihypertensive ho vivo, empa e na le phello e fokolang ho sekhahla sa pelo le phallo ea pelo.Ka lebaka la mofuta oa eona o moholo oa hydrophobic le ho qhibiliha ho matla ha lipid, locarbodipine e ajoa ka potlako ho lisele le litho tsa 'mele ka mor'a hore e kene' meleng, e tlamahane haufi le lera la lisele tsa mesifa, ebe e lokolloa butle.Ka hona, le hoja serum ea lithethefatsi ena e na le nako e khutšoanyane ea ho felisa halofo ea ho hlōleha, phello ea eona e tšoarella nako e telele.
Nako ea poso: Apr-15-2022